Care is taken to avoid physical damage while handling. They have an anisotropic structure, a thin skin-like top layer with a highly porous underlying support. If torqued properly, the nuts should reach the set torque value at about the same time. The volume of flushing agent and flushing time to achieve the required minimum level of extractables may be greater for first time use of cassettes compared to subsequent use and will depend on the porosity of the membrane and the temperature of the flushing solution. Adjust the feed pump flow rate to generate the desired transmembrane pressure TMP. Direct the retentate and permeate lines to waste. But our commitment to you hardly ends here. Each cassette is supplied with:
When opening the expansion tank, wear gloves and other appropriate More information. They are for use by. Pall process engineers have extensive experience in TFF system design and are available to help you with your engineering questions Ports and Flow Rate The permeate side of most TFF cassette holders have two ports. Adjust the feed pump flow rate to generate the desired transmembrane pressure TMP. Rinse the silicone gaskets supplied with the cassettes with deionized or pharmaceutical grade water. The specifications detailed in this document do not apply to other Pall tangential flow filtration membranes and cassettes.
Refer to the MSDS for proper protection and handling instructions. Powder-free gloves should be worn throughout the entire procedure. Fill the feed tank with water or attach feed line to water supply. It also equilibrates the system temperature to the product temperature. The weight of permeate collected can be used to calculate permeate volumes. Preconditioning and post-use conditioning are covered in Sections 4 and 5 of this manual.
On Pall AT hydraulic closure systems, it also depends on the diameter of the pistons. User s Guide to: The user must evaluate and validate the effectiveness of the process with respect to time and dassette and the effectiveness of the sanitizing agent for their process.
T-Series TFF Cassettes with Omega Membrane Care and Use Procedures – PDF
cssette Flush the cassette and hardware assembly with pharmaceutical-grade water. Temperature sensors may also be located at the feed tank, on the feed line after the pump, and on the permeate line. Open the cassette package carefully! Preconditioning T-Series Cassettes and Systems Before processing product, several steps must be performed Figure 14 to assure that the cassettes are properly installed in the holder and fit-for-use to prevent possible sample loss or contamination from storage agents.
Sanitization 8 and 9. The cut line should bisect the channel holes while providing about 2 cm 0. Check the water level in the feed tank and refill if necessary. Start display at page:.
Then return the line to the feed tank. Figure 7 Cassette Package in Inner Bag 4.
Figure 8 Opening Inner Bag The volume of flushing agent and flushing time to achieve the required minimum level of extractables may be greater for first time use of cassettes compared to subsequent use and will depend on the porosity of the membrane and the temperature of the flushing solution. Tank design cassefte affects the minimum volume required to prevent air from getting into the system. This will clean up any holes that More information.
Therefore, it is recommended that you replace gaskets every six months, or more frequently if a gasket appears to be damaged or you repeatedly open and close the holder. Recirculate for 30 minutes.
SM is a service mark of Pall Corporation. If your application requires multiple cassettes, continue the same gasket-cassettegasket pattern, ending with a gasket between the last cassette and the end plate Figure This polymeric membrane is stable against biological and physical degradation due centeamate the unique chemical properties of PES.
Step 3 flushes out the sanitizing agent and reduces extractables to acceptable levels. Installing the first cassette in a holder requires two gaskets. Extended shelf life studies are ongoing. Therefore, tighten the nuts slowly to prevent exceeding the required torque value.
Pall Life Sciences Centramate T-series OS030T02 TFF Cassette 30kd
Run for 30 minutes. Add this document to saved.
Install multiple cassettes with the printed cassette information all facing the same side and direction. Phoenix Vessel Technology Limited. Care is taken to seies physical damage while handling. Step 2 is designed to reduce or eliminate bioburden from the cassette and to extract most of the remaining storage agents.
The information provided in this literature was reviewed for accuracy at the time of publication. Each cassette is supplied with: